This longitudinal case study identifies corporate governance responses in a Chinese state-owned enterprise facing institutional logic multiplicity and demands to shoulder sociopolitical responsibilities beyond economic responsibility. We find that overseas listing led to the incorporation of market logic into an enterprise in which party-state logic prevailed. The prioritization of sociopolitical responsibilities vis-à-vis economic responsibility has shifted through three phases, reflecting changes in institutional logic centrality amid changing politico-institutional and firm conditions. In response, the enterprise developed hybrid corporate governance structures based (...) first on decoupling (2001–2011) and then on translation of a “foreign” corporate governance model to fit the domestic context (2012–2016) but has since sought to dehybridize by strengthening the state-controlled governance structure (2017–2019). Our study contributes to the varieties-of-capitalism approach to corporate governance and offers perspectives on institutional change, institutional logic, and hybrid organizing as well as the implicit ethical issue. (shrink)

Background: Cognitive impairment is one of the core symptoms of schizophrenia, which is considered to be significantly correlated to prognosis. In recent years, many studies have suggested that metabolic disorders could be related to a higher risk of cognitive defects in a general setting. However, there has been limited evidence on the association between metabolism and cognitive function in patients with early-stage schizophrenia.Methods: In this study, we recruited 172 patients with early-stage schizophrenia. Relevant metabolic parameters were examined and cognitive function (...) was evaluated by using the MATRICS Consensus Cognitive Battery (MCCB) to investigate the relationship between metabolic disorder and cognitive impairment.Results: Generally, the prevalence of cognitive impairment among patients in our study was 84.7% (144/170), which was much higher than that in the general population. Compared with the general Chinese setting, the study population presented a higher proportion of metabolic disturbance. Patients who had metabolic disturbance showed no significant differences on cognitive function compared with the other patients. Correlation analysis showed that metabolic status was significantly correlated with cognitive function as assessed by the cognitive domain scores (p < 0.05), while such association was not found in further multiple regression analysis.Conclusions: Therefore, there may be no association between metabolic disorder and cognitive impairment in patients with early-stage schizophrenia.Trial Registration: Clinicaltrials.gov, NCT02880462. Registered August 26, 2016. (shrink)

Electroacupuncture (EA) and electroconvulsive therapy (ECT) are often used in the management of schizophrenia. This study sought to determine whether additional EA and ECT could augment antipsychotic response and reduce related side effects. In this retrospective controlled study, 287 hospitalized schizophrenic patients who received antipsychotics (controls, n = 50) alone or combined with EA (n = 101), ECT (n = 55) or both (EA+ECT, n = 81) were identified. EA and ECT were conducted for 5 and 3 sessions per week, (...) respectively, with a maximum of 12 sessions for ECT during hospitalization. The Scale for the Assessment of Positive Symptoms (SAPS) and Scale for the Assessment of Negative Symptoms (SANS) were used to assess the severity of psychotic symptoms. Clinical response on SAPS and SANS, weight gain, and adverse events were compared. Survival analysis revealed that the ECT and EA+ECT groups had markedly greater clinical response rate than controls on SAPS [72.7% and 90.1% vs. 64.0%; relative risk (RR), 1.974 and 2.628, respectively, P ≤ 0.004] and on SANS (67.3% and 70.4% vs. 42.0%; RR, 1.951 and 2.009, respectively, P ≤ 0.015). A significantly greater response rate on SANS than controls was also observed in the EA group (64.4% versus 42.0%; RR = 1.938, P = 0.008). EA-containing regimens remarkably reduced weight gain and incidences of headache, insomnia, dry mouth, and electrocardiographic abnormalities. These results suggest that EA and ECT can serve as additional treatment for enhancing antipsychotic response and reduce the side effects in hospitalized patients with schizophrenia. (shrink)

BackgroundIn the early days of COVID-19 outbreak, the normally orderly health system was severely challenged by large numbers of feverish patients and shortage of healthcare workers. The outbreak played a harmful role in the mental health of these healthcare workers.ObjectiveWe aim to assess the prevalence of moderate or severe anxiety and depression symptoms of healthcare workers in different regions during COVID-19 disaster and identify the potential risk factors.MethodsWe did a cross-sectional study on ADS of healthcare workers in epicenter-Hubei province and (...) regions in lower epidemic-other provinces by questionnaire online. The data of ADS, the demographic characteristics, occupational exposure, physical condition, family situation, and coping styles were collected and analyzed.ResultsA total of 24.68% of the respondents had experienced moderate or severe ADS. Moderate or severe ADSs were in a higher prevalence in Hubei than other provinces. Suspicious symptoms on their own and in family members were independent risk factors of moderate or severe ADS of all health workers. Working on the frontline was the independent risk factor for participants in Hubei province, whereas quarantine was the independent risk factor for those in other provinces. Moreover, among all participants, those with negative coping style were more than four times more likely to have moderate or severe ADS than those with positive coping style.ConclusionModerate or severe ADSs were in a higher prevalence in healthcare workers of Hubei province during COVID-19 outbreak. The coping style may have major impact on ADS in such situation. (shrink)

Automated reasoning issues are addressed for a finite lattice-valued propositional logic LnP(X) with truth-values in a finite lattice-valued logical algebraic structure—lattice implication algebra. We investigate extended strategies and rules from classical logic to LnP(X) to simplify the procedure in the semantic level for testing the satisfiability of formulas in LnP(X) at a certain truth-value level α (α-satisfiability) while keeping the role of truth constant formula played in LnP(X). We propose a lock resolution method at a certain truth-value level α (α-lock (...) resolution) in LnP(X) and have proved its theorems of soundness and weak completeness, respectively. We provide more efficient resolution based automated reasoning in LnP(X) and key supports for α-resolution-based automated reasoning approaches and algorithms in lattice based linguistic truth-valued logic. (shrink)

Aiming at the vulnerability of wireless network, this paper proposed a method of WiFi penetration testing based on Kali Linux which is divided into four stages: preparation, information collection, simulation attack, and reporting. By using the methods of monitoring, scanning, capturing, data analysis, password cracking, fake wireless access point spoofing, and other methods, the WiFi network penetration testing with Kali Linux is processed in the simulation environment. The experimental results show that the method of WiFi network penetration testing with Kali (...) Linux has a good effect on improving the security evaluation of WiFi network. (shrink)

ObjectiveThis study took users of short-form mobile videos as research participants to explore the role of their boredom proneness in mediating the relationship between the use of mobile social media and subjective well-being.MethodsA sample of 656 users was evaluated by the Problematic Mobile Social Media Usage Assessment Questionnaire, General Well-Being Schedule, and Boredom Proneness Scale.ResultsFirstly, significant interactions were found between monthly living expenses and the UMSM of the participants, which were recognized as factors affecting SWB. Secondly, the level of living (...) expenses had little effect on the high-level and low-level groups of the UMSM but imposed a significant impact on the medium-level group. Thirdly, the UMSM showed an influence that could positively predict boredom; both the UMSM and boredom demonstrated a negative predictive effect on SWB.ConclusionThe findings indicate that the inappropriate use of mobile social media negatively affects users’ subjective well-being; boredom partially mediated the relationship between the use of mobile social media and SWB. (shrink)

The structure and “metabolism” (movement and conversion of goods and energy) of urban areas has caused cities to be identified as “super‐organisms”, placed between ecosystems and the biosphere, in the hierarchy of living systems. Yet most such analogies are weak, and render the super‐organism model ineffective for sustainable development of cities. Via a cluster analysis of 15 shared traits of the hierarchical living system, we found that industrialized cities are more similar to eukaryotic cells than to multicellular organisms; enclosed systems, (...) such as factories and greenhouses, paralleling organelles in eukaryotic cells. We further developed a “super‐cell” industrialized city model: a “eukarcity” with citynucleus (urban area) as a regulating centre, and organaras (enclosed systems, which provide the majority of goods and services) as the functional components, and cityplasm (natural ecosystems and farmlands) as the matrix. This model may improve the vitality and sustainability of cities through planning and management. (shrink)

Employee innovation is the cornerstone of the organization, and the motivation for employee innovative behavior largely depends on the leadership style of the leader. With the economic development of society, the traditional authoritative style of leadership can no longer adapt to the psychological characteristics of employees, who use new-era work concepts, techniques, and social rules (hereafter, new generation workers). Inclusive leadership is based on the concept of “fully inclusive and equitable” in traditional Chinese culture, and it can adapt to the (...) independent needs of new generation employees. At present, the research on the relationship between the traditional leadership style and employee innovative behavior is relatively extensive, but there is little research on the relationship between inclusive leadership style and employee innovative behavior, and this needs further exploration. This paper takes new generation employees as the sample and uses psychological capital as an intermediary variable to explore the influence of inclusive leadership style on the innovative behaviors of new generation employees. We found that inclusive leadership is significantly and positively related to new generation employees’ innovative behaviors. Theoretical and practical implications are discussed. (shrink)

In this note we shall show that if L is a balanced pseudocomplemented Ockham algebra then the set ${\fancyscript{I}_{k}(L)}$ of kernel ideals of L is a Heyting lattice that is isomorphic to the lattice of congruences on B(L) where ${B(L) = \{x^* | x \in L\}}$ . In particular, we show that ${\fancyscript{I}_{k}(L)}$ is boolean if and only if B(L) is finite, if and only if every kernel ideal of L is principal.

As the most frequently used tool for measuring empathy, the Interpersonal Reactivity Index (IRI) is often scored by researchers arbitrarily and casually. Many commonly used IRI scoring approaches and their corresponding measurement models are unverified, which may make the conclusions of subsequent variable relation studies controversial and even misleading. We make the first effort to summarize these measurement models and to evaluate rationality of the common scoring methods of the IRI by confirmatory factor analysis, focusing on model fitting, factor loading, (...) and model-based reliability simultaneously. The results show that most of these models do not fit well, indicating that the scoring approaches of the IRI corresponding to these models may be problematic. Relatively speaking, better scoring approaches of the IRI include summing empathic concern and perspective taking as the total score of the IRI and reporting the score of perspective taking as cognitive empathy. (shrink)

BackgroundBilateral cerebral palsy is the most common type of CP in children and is often accompanied by different degrees of communication impairment. Several studies have attempted to identify children at high risk for communication impairment. However, most prediction factors are qualitative and subjective and may be influenced by rater bias. Individualized objective diagnostic and/or prediction methods are still lacking, and an effective method is urgently needed to guide clinical diagnosis and treatment. The aim of this study is to develop and (...) validate an objective, individual-based model for the prediction of communication impairment in children with BCP by the time they enter school.MethodsA multicenter prospective cohort study will be conducted in four Chinese hospitals. A total of 178 children with BCP will undergo advanced brain magnetic resonance imaging at baseline. At school entry, communication performance will be assessed by a communication function classification system. Three-quarters of children with BCP will be allocated as a training cohort, whereas the remaining children will be allocated as a test cohort. Multivariate lesion- and connectome-based approaches, which have shown good predictive ability of language performance in stroke patients, will be applied to extract features from MR images for each child with BCP. Multiple machine learning models using extracted features to predict communication impairment for each child with BCP will be constructed using data from the training cohort and externally validated using data from the test cohort. Prediction accuracy across models in the test cohort will be statistically compared.DiscussionThe findings of the study may lead to the development of several translational tools that can individually predict communication impairment in children newly diagnosed with BCP to ensure that these children receive early, targeted therapeutic intervention before they begin school.Trial registrationThe study has been registered with the Chinese Clinical Trial Registry. (shrink)

The generalized Brans–Dicke theory (GBD), as one of the modified gravitational theories, was proposed previously and some interesting properties were found in this theory. Here we investigate the traversable-wormhole physics for GBD theory. Firstly, we derive the gravitational field equation in the framework of GBD wormhole geometry. The traversable wormhole could be gained in this theory. Secondly, using the classical reconstruction technique we originally derive an Lagrangian function for describing gravity in GBD theory. And the derived Lagrangian function for gravity (...) could be satisfied with the requirement of the viable conditions, such as the local gravity tests and the cosmological constraints, etc. Thus, the viable model for cosmology, local gravity and traversable WH can be unified in a uniform Lagrangian quantity within the framework of GBD theory. Thirdly, given that the violation of the energy conditions (ECs) often induce some problems in theory, we explore the ECs of matter in the traversable wormhole. It is shown that the null EC, the weak EC and the dominated EC for the matter can be satisfied in the traversable-wormhole physics of GBD theory, which are different from the results given in GR. It seems that the theory of GBD owns the more logic technically and consistency formally than the theory of GR. Fourthly, some other properties of GBD traversable WH are explored, such as the total gravitational energy, the volume integral quantifier, the dynamical stability of the anisotropic matter, and the difference of the propagation of sound within the matter configuration. The results support the GBD to provide an interesting candidate for traversable WH. (shrink)

This paper aims to explore whether the usage of credit cards has peer effects in rural areas of China. The results suggest that the usage of credit cards will be affected by the behavior of other farmers; namely, the usage of credit cards has peer effects in rural areas. We also verify that women, older, and low-academic farmers show stronger peer effects. The results emphasize that, compared with the mass farmers and vulnerable farmers, the usage of elite farmers is more (...) likely to affect the same behaviors of other farmers. Our study contributes to prior literature by giving empirical insights into the consequences of peer effects on the credit card usage of farmers, which conduces to a better understanding of the financial decision-making of farmers. The research may provide a practical implication for the optimal design of policy interventions. On the one hand, banks and other financial institutions can promote innovative financial products in rural areas with the help of peer effects; on the other hand, regulators can regulate farmers’ wrong financial behaviors by the social multiplier of peer effects to reduce systemic risks in rural finance. (shrink)

This study explored the chain-mediating roles of optimism and mental health in the relation of self-directed learning with academic performance among college students in Wuhan during long-term online teaching. In total, 473 valid responses were obtained from students at three Wuhan universities. Self-directed learning, optimism, mental health, and academic performance scales were used as measurement instruments; a 5-point Likert scale was employed for all items. To examine the instruments’ reliability and validity, a measurement model was constructed; moreover, structural models were (...) employed for assessing the chain mediation model. This study confirmed that self-directed learning was a positive predictor of academic performance in Wuhan college students. Optimism and mental health were two mediators and partially jointly mediated the relation of self-directed learning with academic performance. The results revealed that self-directed learning only partially positively predicted academic performance. The aforementioned relationship was partially mediated by optimism and mental health, highlighting the essential roles of optimism and mental health in the learning and learning outcomes of Wuhan college students. (shrink)

Hemispherical Resonator Gyro is a new type gyro with high precision, high reliability, shock resistance, no need of preheating, short start time, and long life. It is a kind of vibrating gyro with standing wave rotating along the sensitive base of annular precession, has a unique application prospect in the field of high precision inertial sensors, and is widely used in unmanned aerial vehicle control in complex environments. Based on the theory of the structure characteristics of the hemispherical resonator, the (...) mathematical model of energy of the resonator is established to research the rule of resonant frequency when the hemispherical resonator is rotated around the central axis. In this paper, the influence of precession factor, which are the top angle, the bottom angle, and wall unevenness of the hemispherical resonator, are analyzed. A series of hemispherical resonator models are constructed by ANSYS software to prove the results of theoretical research. The simulation results show that precession factor of the hemispherical resonator is more sensitive of the top angle than the bottom angle, and the error of angular velocity which is caused by the change of the top angle is larger than that which is caused by the change of the bottom angle. (shrink)

Past research suggests that spiritual leadership plays a pivotal role in enhancing employee job performance, yet we have little understanding of how and when spiritual leadership enhances employee job performance. The present study explores how and when spiritual leadership promotes job performance by examining relational energy as a mediator and leader integrity and relational energy differentiation as boundary conditions. We tested the theoretical model with data gathered across three phases over 12 months from 497 employees and their supervisors in 108 (...) groups. Results showed that the positive relationship between spiritual leadership and job performance was mediated by relational energy. Moreover, we found that leader integrity amplified the mediated relationship between spiritual leadership and employee job performance via relational energy. In contrast, relational energy differentiation weakened this mediated relationship. (shrink)

We used social network analysis to examine a theoretical model exploring why, and under what circumstances, the perpetrators’ ostracizing behaviors are accurately perceived by the target employees. In turn, these perceptions of ostracism lead to the target employees’ counterproductive work behaviors. Adopting perspectives from both perpetrators and targets, we directly measured the ostracizing behaviors by all potential perpetrators and perceived workplace ostracism by target employees. We integrate Social information processing theory and conservation of resource theory to propose a moderated mediation (...) model, and found that employees who have a high level of need to belong are more likely to capture coworkers’ ostracizing behaviors, and those with low political skill are more likely to engage in counterproductive work behavior as their reaction to perceived workplace ostracism. Theoretical and practical implications are discussed. (shrink)

The Meaning in Life Questionnaire is a popular tool to measure the presence of and one’s search for meaning in life. Although the validity of the MLQ has been verified in previous studies, the evidence from longitudinal measurement invariance of the MLQ is still lacking. The current study aimed to examine the LMI of the MLQ in a sample of Chinese college students at a 1-year interval. Multigroup confirmatory factor analysis was used to examine the LMI of the MLQ over (...) four time points. Results indicate that the MLQ has strict longitudinal invariance across 1-year in Chinese college students, and the latent means difference of MLQ-P is not significant differences across time, while the latent means difference of MLQ-S show significant differences between Time 1 and the other time points. Moreover, the internal consistency reliabilities of the MLQ scores were acceptable at all four time points, and the stability coefficients across time were moderate. These findings provide preliminary evidence that the MLQ has satisfactory longitudinal properties in Chinese college students. (shrink)

This article reports on the evolution of breakdance. Given the inclusion of breakdancing in the 2024 Olympic Games in Paris, France, scholars have generated substantial international research related to breakdance teaching in recent years. However, few researchers have focused on the impact of formal formative assessment on breakdance teachers’ teaching and students’ learning. We wish to contribute to the quality of breakdance teaching and learning by identifying the positive impact of recent research on formative assessment on student learning and designing (...) a formal formative assessment task related to breakdance. This article lays out a framework of formal formative assessment tasks and identifies the positive impact of formative assessment on dance education. Although our work is far from perfect, it does provide a general methodological framework for assessing breakdance students’ abilities in formal educational settings. (shrink)

ObjectiveThis study aims to investigate the effectiveness of mindfulness-based cognitive therapy combined with medication therapy in preventing the recurrence of major depressive disorder in convalescent patients.MethodsA total of 130 patients with convalescent MDD were enrolled in this prospective study. Sixty-five patients were assigned to the experimental group and received medication therapy combined with MBCT, and 65 patients were assigned to the control group and treated with medication alone. The recurrence rate and related hormonal changes were compared between the two groups.ResultsAfter (...) 1 year of MBCT intervention, eight patients experienced recurrence in the experimental group, a recurrence rate of 12.31%, and 19 patients experienced recurrence in the control group, a recurrence rate of 29.23%. The Hamilton Depression Rating Scale and the World Health Organization Quality of Life Scale scores in both the experimental and the control groups were significantly improved after treatment. The difference in the HAM-D scores before and after treatment in the experimental group was 16.74 ± 4.54; this was significantly higher than that of the control group. The WHOQOL-BREF scores in the experimental group were significantly improved compared with those of the control group. The differences in the levels of corticotrophin-releasing hormone, adrenocorticotropic hormone, and cortisol before and after treatment in the experimental group and the control group were statistically significant. The difference in CRH before and after treatment in the experimental group was 16.8 ± 7.2, which was higher than that of the control group. The intervention with MBCT had a significant impact on the recurrence of MDD [β = 1.206, P = 0.039, 95% CI = 0.0790–1.229]. The difference in the HAM-D scores also had a significant impact on the recurrence of MDD.ConclusionCompared with medication therapy alone, the use of MBCT combined with medication therapy can effectively prevent the recurrence of MDD in convalescent patients. (shrink)

Resumo: Não apenas as famílias aristocráticas indígenas, mas também as famílias de imigrantes do norte que viviam no Leste de Zhejiang, estavam envolvidas nos debates sobre teoria monetária e pensamento político, na Dinastia Jin Oriental e Dinastias do Sul. Os debates geralmente se concentravam nos preços das commodities e no trabalho forçado no Leste de Zhejiang. Esse fenômeno histórico especial reflete duas questões. Por um lado, o caos causado pela guerra no Norte e as famílias de estudiosos, migrando para o (...) Sul, promoveram muito o desenvolvimento do Sul da China, o que tornou os cinco condados do leste de Zhejiang as áreas mais importantes e ativas da economia. Por outro lado, reflete as mudanças de relacionamento entre imigrantes e nobres indígenas. Ou seja, as famílias aristocráticas indígenas e as famílias imigrantes do Norte cooperaram na economia para aumentar a prosperidade e o desenvolvimento do Leste de Zhejiang. Mais tarde, com o surgimento de “povo comum (寒人)”, o status econômico dos estudiosos foi cada vez mais impactado, o que resultou em ansiedade e consciência de crise dos nobres. (shrink)

Rather than being a form of explicitly commodified reproduction, informal surrogacy is practiced (and interpreted) in a working-class community in Beijing as part of local affective life, viewed in terms of gifting, favors, filial piety, and family concerns. Through this practice a particular form of biopower, articulated in affective terms, limits some women to serving as instruments of reproduction. Unlike the common western assumption of a physical body as separate from the experiencing subject, the Chinese body has a subjective, experiential (...) dimension. This subjective body harbors an agency with the potential to transform the power exercised on it and to impact the circumstances of the surrogate’s life. I contextualize such agency in the analysis of the ambivalence of these women toward surrogacy and the violence of local kinship systems. Through analyzing how surrogates use their bodies to transform codes, forces and reform the self, the article suggests that informal surrogacy interacts and shapes local affective and political economies. (shrink)

The brain-computer interface based on functional near-infrared spectroscopy has received more and more attention due to its vast application potential in emotion recognition. However, the relatively insufficient investigation of the feature extraction algorithms limits its use in practice. In this article, to improve the performance of fNIRS-based BCI, we proposed a method named R-CSP-E, which introduces EEG signals when computing fNIRS signals’ features based on transfer learning and ensemble learning theory. In detail, we used the Independent Component Analysis algorithm for (...) the correspondence between the sources of the two signals. We then introduced the EEG signals when computing the spatial filter based on a modified Common Spatial Pattern algorithm. Experimental results on public datasets show that the proposed method in this paper outperforms traditional methods without transfer. In general, the mean classification accuracy can be increased by up to 5%. To our knowledge, it is an innovation that we tried to apply transfer learning between EEG and fNIRS. Our study’s findings not only prove the potential of the transfer learning algorithm in cross-model brain-computer interface, but also offer a new and innovative perspective to research the hybrid brain-computer interface. (shrink)

In organisms, ribonucleic acid plays an essential role. Its function is being discovered more and more. Due to the conserved nature of RNA sequences, its function mainly depends on the RNA secondary structure. The discovery of an approximate relationship between two RNA secondary structures helps to understand their functional relationship better. It is an important and urgent task to explore structural similarities from the graphical representation of RNA secondary structures. In this paper, a novel graphical analysis method based on the (...) triple vector curve representation of RNA secondary structures is proposed. A combinational method involving a discrete wavelet transform and fractal dimension with sliding window is introduced to analyze and compare the graphs derived from feature extraction; after that, the distance matrix is generated. Then, the distance matrix is analyzed by clustering and visualized as a clustering tree. RNA virus and noncoding RNA datasets are applied to perform experiments and analyze the clustering tree. The results show that the proposed method yields more accurate results in the comparison of RNA secondary structures. (shrink)

It is of great significance to predict the results accurately based on the statistics of sports competition for participants research, commercial cooperation, advertising, and gambling profit. Aiming at the phenomenon that the PageRank page sorting algorithm is prone to subject deviation, the category similarity between pages is introduced into the PageRank algorithm. In the PR value calculation formula of the PageRank algorithm, the factor W between pages is added to replace the original Nu. In this way, the content category between (...) pages is considered, and the shortcoming of theme deviation will be improved. The time feedback factor in the PageRank-time algorithm is used for reference, and the time feedback factor is added to the first improved PR value calculation formula. Based on statistics from 1230 games during the NBA 2018-2019 regular season, this paper ranks the team strength with improved PageRank algorithm and compares the results with the ranking of regular-season points and the result of playoffs. The results show that it is consistent with the regular-season points ranking in the eastern division by the use of improved PageRank algorithm, but there is a difference in the second ranking in the western division. In the prediction of top four in playoffs, it predicts three of the four teams. (shrink)

The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)